Baraban Scott C, Tallent Melanie K
Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, San Francisco, CA 94143-0520, USA.
Trends Neurosci. 2004 Mar;27(3):135-42. doi: 10.1016/j.tins.2004.01.008.
Interneurons are often classified according to neuropeptide content. However, it is becoming increasingly clear that neuropeptides are more than convenient neurochemical markers and can act as important modulators of neuronal activity. Recent advances in understanding neuropeptide release and physiological actions suggest that the interneuronal system of neuropeptides is crucial for maintaining appropriate brain function under normal and pathophysiological conditions. In particular, interneuronal neuropeptides appear to play roles in cognition and as endogenous anti-epileptic agents. This article describes current understanding of the conditions under which neuropeptides are released from interneurons, their specific effects on neuronal excitability and synaptic transmission, and the consequences of their loss of function.
中间神经元通常根据神经肽含量进行分类。然而，越来越清楚的是，神经肽不仅仅是方便的神经化学标志物，还可以作为神经元活动的重要调节因子。在理解神经肽释放和生理作用方面的最新进展表明，神经肽中间神经元系统对于在正常和病理生理条件下维持适当的脑功能至关重要。特别是，中间神经元神经肽似乎在认知中发挥作用，并作为内源性抗癫痫剂。本文描述了目前对神经肽从中间神经元释放的条件、它们对神经元兴奋性和突触传递的具体影响以及它们功能丧失的后果的理解。
