恒河猴（猕猴）的阿尔茨海默病β淀粉样蛋白疫苗接种

Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta).

作者信息

Gandy Sam, DeMattos Ron B, Lemere Cynthia A, Heppner Frank L, Leverone Jodi, Aguzzi Adriano, Ershler William B, Dai Jinlu, Fraser Paul, St George Hyslop Peter, Holtzman David M, Walker Lary C, Keller Evan T

机构信息

Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA.

出版信息

Mech Ageing Dev. 2004 Feb;125(2):149-51. doi: 10.1016/j.mad.2003.12.002.

DOI:10.1016/j.mad.2003.12.002

PMID:15037022

Abstract

Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). Immunized monkeys developed anti-Abeta titers exceeding 1:1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta.

摘要

近期的初步数据表明，用阿尔茨海默病β淀粉样蛋白进行疫苗接种可能会减少人类阿尔茨海默病中的老年斑负荷并稳定认知衰退。为了在与人类关系更密切的物种中研究抗β淀粉样蛋白抗体形成的机制及后果，给恒河猴（猕猴）接种了聚集的β淀粉样蛋白（1-42）。免疫后的猴子产生的抗β淀粉样蛋白滴度超过1:1000，并且它们血浆中的β淀粉样蛋白水平比接种聚集胰岛淀粉样多肽的猴子所观察到的血浆β淀粉样蛋白水平高5至10倍。这些数据支持使用非人类灵长类动物来模拟与用聚集的阿尔茨海默病β淀粉样蛋白给人类接种相关的某些现象。