Stjernschantz Johan
Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden.
Exp Eye Res. 2004 Apr;78(4):759-66. doi: 10.1016/j.exer.2003.11.016.
This review summarizes the Ernst H. Bárány Prize Lecture given at the meeting of the International Society of Eye Research in Geneva 2002. In the paper the path from the author's early studies on neurogenic inflammation in the eye to the search for a suitable prostaglandin analogue for glaucoma treatment, and the development of latanoprost are described. In particular the solution to the nociceptive and hyperemic side-effects of naturally occurring prostaglandins in the eye, the mechanism of action of FP prostanoid receptor agonists as well as the selection of dose for glaucoma treatment are discussed. In addition, pharmacokinetical aspects of latanoprost, and the melanogenic side-effect of prostaglandins in the iris are addressed. The paper is primarily focused on studies performed by the author and complete reference to other previous, or contemporary studies is therefore not always given as the purpose is not to present a comprehensive review article.
本综述总结了2002年在日内瓦国际眼研究学会会议上发表的恩斯特·H·巴拉尼奖讲座内容。该论文描述了作者从早期关于眼部神经源性炎症的研究，到寻找适合治疗青光眼的前列腺素类似物，以及拉坦前列素的研发历程。特别讨论了眼部天然前列腺素的伤害性和充血性副作用的解决方案、FP前列腺素受体激动剂的作用机制以及青光眼治疗剂量的选择。此外，还探讨了拉坦前列素的药代动力学方面以及前列腺素在虹膜中的致黑副作用。本文主要聚焦于作者所进行的研究，因此并不总是完整引用其他先前或当代的研究，因为目的并非呈现一篇全面的综述文章。
