肌球蛋白超家族中生物化学与功能的关联。
Relating biochemistry and function in the myosin superfamily.
作者信息
De La Cruz Enrique M, Ostap E Michael
机构信息
Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520, USA.
出版信息
Curr Opin Cell Biol. 2004 Feb;16(1):61-7. doi: 10.1016/j.ceb.2003.11.011.
All characterized myosins share a common ATPase mechanism. However, detailed kinetic analyses suggest that modulation of the rate and equilibrium constants that define the ATPase cycle confers specific properties to these motor proteins, suiting them to specific physiological tasks. Understanding the kinetic mechanisms allows potential cellular functions of the different myosin classes and isoforms to be better defined.
所有已被表征的肌球蛋白都具有共同的ATP酶机制。然而，详细的动力学分析表明，对定义ATP酶循环的速率和平衡常数的调节赋予了这些运动蛋白特定的属性，使其适合特定的生理任务。了解动力学机制有助于更好地界定不同类别和亚型肌球蛋白的潜在细胞功能。
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