Vogelmann Roger, Amieva Manuel R, Falkow Stanley, Nelson W James
Department of Molecular and Cellular Physiology, Beckman Center B121, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305-5435, USA.
Curr Opin Cell Biol. 2004 Feb;16(1):86-93. doi: 10.1016/j.ceb.2003.12.002.
The epithelial apical-junctional complex is a key regulator of cellular functions. In addition, it is an important target for microbial pathogens that manipulate the cell to survive, proliferate and sometimes persist within a host. Out of a myriad of potential molecular targets, some bacterial and viral pathogens have selected a subset of protein targets at the apical-junctional complex of epithelial cells. Studying how microbes use these targets also teaches us about the inherent physiological properties of host molecules in the context of normal junctional structure and function. Thus, we have learned that three recently uncovered components of the apical-junctional complex of the Ig superfamily--junctional adhesion molecule, Nectin and the coxsackievirus and adenovirus receptor--are important regulators of junction structure and function and represent critical targets of microbial virulence gene products.
上皮顶端连接复合体是细胞功能的关键调节因子。此外，它是微生物病原体的重要靶点，这些病原体通过操纵细胞在宿主体内存活、增殖，有时还能持续存在。在众多潜在的分子靶点中，一些细菌和病毒病原体选择了上皮细胞顶端连接复合体中的一部分蛋白质靶点。研究微生物如何利用这些靶点，也让我们了解了在正常连接结构和功能背景下宿主分子的固有生理特性。因此，我们已经了解到，免疫球蛋白超家族顶端连接复合体最近发现的三个组分——连接黏附分子、NECTIN和柯萨奇病毒及腺病毒受体——是连接结构和功能的重要调节因子，也是微生物毒力基因产物的关键靶点。
