Gandini D, Lanza F, Latorraca A, del Senno L
Istituto di Chimica Biologica, Università degli Studi di Ferrara.
Boll Soc Ital Biol Sper. 1992 Jan;68(1):39-45.
Ig gene analysis, carried out in 25 patients failed to show rearrangement patterns typical of each stage, but, nevertheless, confirmed the monoclonal origin of leukemic cells in these patients. In addition, in 14 of them the pattern of Ig gene rearrangements measured on two different occasions was analyzed. Only in patients who had received chemotherapy, the intensity of the Ig germline band was greater than that of the rearranged bands, indicating the reduction of lymphocytosis after the therapy. Thus, though Ig gene rearrangement could not distinguish the CLL stage, our data confirm the usefulness, at all clinical stages, of Ig gene analysis as a tool in the evaluation of the efficiency of the therapy.
对25例患者进行的Ig基因分析未能显示出各阶段典型的重排模式，但尽管如此，仍证实了这些患者白血病细胞的单克隆起源。此外，对其中14例患者在两个不同时间点测得的Ig基因重排模式进行了分析。仅在接受化疗的患者中，Ig种系条带的强度大于重排条带，表明治疗后淋巴细胞增多症有所减轻。因此，虽然Ig基因重排无法区分慢性淋巴细胞白血病（CLL）的阶段，但我们的数据证实了在所有临床阶段，Ig基因分析作为评估治疗效果的工具是有用的。
