Rades Dirk, Schild Steven E, Fehlauer Fabian
Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Neurology. 2004 Mar 23;62(6):987-9. doi: 10.1212/01.wnl.0000115392.21898.e3.
Although central neurocytomas are generally described as benign CNS lesions, malignant behavior including craniospinal dissemination and tumor-related death may occur. This meta-analysis was performed to investigate the prognostic value of the MIB-1 labeling index. Data were obtained not from the literature alone but also from contact with the authors. The data suggested an MIB-1 index score of >3% to be associated with a worse prognosis for local control (p < 0.0001) and survival (p = 0.0004).
尽管中枢神经细胞瘤通常被描述为良性中枢神经系统病变，但仍可能出现包括颅脊髓播散和肿瘤相关死亡在内的恶性行为。进行这项荟萃分析以研究MIB-1标记指数的预后价值。数据不仅从文献中获取，还通过与作者联系获得。数据表明，MIB-1指数评分>3%与局部控制预后较差（p<0.0001）和生存预后较差（p = 0.0004）相关。
