Ivanyi P
Department of Transplantation Immunology, Central Laboratory Blood Transfusion Service, Amsterdam, The Netherlands.
Curr Opin Rheumatol. 1992 Aug;4(4):484-93.
This review discusses recent data relevant to better understanding the HLA-B27 association with seronegative spondyloarthropathies. Although much is known about the B27 molecule, its contribution to the pathogenesis of disease is unclear. It is still unknown whether the B27 molecule is involved directly, and whether this is due to the basic function of the molecule, ie, presentation of allele-specific antigenic peptides to the T-cell receptor. Experiments performed with B27 transgenic mice and rats strongly support the view that some unique or special property of the B27 molecule is involved in pathogenesis. However, the data are of a preliminary nature.
本综述讨论了近期的数据，这些数据有助于更好地理解HLA - B27与血清阴性脊柱关节病的关联。尽管对B27分子已有很多了解，但其在疾病发病机制中的作用尚不清楚。B27分子是否直接参与其中，以及这是否归因于该分子的基本功能，即向T细胞受体呈递等位基因特异性抗原肽，目前仍不清楚。对B27转基因小鼠和大鼠进行的实验有力地支持了这样一种观点，即B27分子的某些独特或特殊性质参与了发病机制。然而，这些数据尚属初步性质。
