Davis P
University of Alberta, Heritage Medical Research Centre, Edmonton, Canada.
Curr Opin Rheumatol. 1992 Aug;4(4):529-33.
There is increasing evidence of a role for viruses in the pathogenesis and etiology of rheumatic diseases. Although definitive evidence of any involvement in diseases such as rheumatic arthritis and systemic lupus erythematosus is currently lacking, there is increasing evidence that viruses may be involved in the pathogenesis of related diseases. In particular, the recent world-wide epidemic of human immunodeficiency virus infection has been associated with the identification of a wide variety of rheumatic manifestations, most notably oligoarthropathies, psoriatic arthropathies, and Reiter's-like syndromes. The spectrum of rheumatic diseases associated with human immunodeficiency virus infection appears to be expanding at a considerable rate. Other viruses have also been shown to be associated with rheumatic disorders, most notably hepatitis viruses, human T lymphotropic virus type I, and parvoviruses. In the latter case, acute arthropathies and those resembling rheumatoid arthritis and Lyme arthritis have recently been identified. This review presents some of the evidence in the recently published literature on the role of different viruses and their implications in the pathogenesis of various rheumatic diseases.
越来越多的证据表明病毒在风湿性疾病的发病机制和病因学中发挥作用。尽管目前缺乏病毒参与风湿性关节炎和系统性红斑狼疮等疾病的确切证据，但越来越多的证据表明病毒可能参与相关疾病的发病机制。特别是，最近全球范围内的人类免疫缺陷病毒感染流行与多种风湿性表现的发现有关，最显著的是寡关节炎、银屑病关节炎和赖特氏样综合征。与人类免疫缺陷病毒感染相关的风湿性疾病谱似乎正在以相当快的速度扩大。其他病毒也已被证明与风湿性疾病有关，最显著的是肝炎病毒、人类嗜T淋巴细胞病毒I型和细小病毒。在后一种情况下，最近已发现急性关节炎以及类似类风湿性关节炎和莱姆关节炎的疾病。本综述介绍了最近发表的文献中关于不同病毒的作用及其在各种风湿性疾病发病机制中的影响的一些证据。
