通过腔内注射干扰素-α对转移性乳腺癌和卵巢癌细胞进行抗原调节。
Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.
作者信息
Giacomini P, Mottolese M, Fraioli R, Benevolo M, Venturo I, Natali P G
机构信息
Department of Pathology, Regina Elena Institute, Rome, Italy.
出版信息
Br J Cancer. 1992 Aug;66(2):342-4. doi: 10.1038/bjc.1992.267.
Abstract
Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.
摘要
在接受单次腔内注射18×10⁶ U重组干扰素α后，从乳腺癌和卵巢癌胸腔积液及腹腔积液患者获取的肿瘤细胞中观察到主要组织相容性抗原和肿瘤相关抗原的抗原调制。该治疗方案在11例受试病例中有7例导致了抗原调制，这表明至少一部分乳腺癌和卵巢癌细胞对干扰素α原位生物修饰具有潜在的（尽管有限）反应性。
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本文引用的文献
1
Reactivity of a monoclonal antibody with human ovarian carcinoma.一种单克隆抗体与人卵巢癌的反应性。
J Clin Invest. 1981 Nov;68(5):1331-7. doi: 10.1172/jci110380.
2
3
Immunological analysis of mucin molecules expressed by normal and malignant mammary epithelial cells.正常和恶性乳腺上皮细胞表达的黏蛋白分子的免疫学分析。
Int J Cancer. 1987 Sep 15;40(3):319-27. doi: 10.1002/ijc.2910400307.
4
Differential responsiveness of cloned mammary carcinoma cell populations to the human recombinant leukocyte interferon enhancement of tumor antigen expression.克隆的乳腺癌细胞群体对人重组白细胞干扰素增强肿瘤抗原表达的差异反应性。
Int J Cancer. 1985 Aug 15;36(2):159-66. doi: 10.1002/ijc.2910360206.
5
mAb KUL/05 identifies a denaturation-resistant determinant shared by class II MHC products DR, DQ and DP.单克隆抗体KUL/05识别出由II类主要组织相容性复合体（MHC）产物DR、DQ和DP共享的一个抗变性决定簇。
J Immunogenet. 1989 Jun;16(3):203-16. doi: 10.1111/j.1744-313x.1989.tb00463.x.
6
Interferon therapy in cancer: from imaginon to interferon.癌症中的干扰素疗法：从想象到干扰素。
Cancer Res. 1986 Sep;46(9):4315-29.
7
B-cell growth factor-induced and alpha-interferon-inhibited proliferation of hairy cells coincides with modulation of cell surface antigens.
Cancer Res. 1990 Jul 1;50(13):4111-20.
8
Intraperitoneal recombinant gamma-interferon in patients with recurrent ascitic ovarian carcinoma: modulation of cytotoxicity and cytokine production in tumor-associated effectors and of major histocompatibility antigen expression on tumor cells.复发性腹水型卵巢癌患者腹腔内注射重组γ干扰素：对肿瘤相关效应细胞的细胞毒性和细胞因子产生以及肿瘤细胞上主要组织相容性抗原表达的调节
Cancer Res. 1990 Nov 15;50(22):7318-23.
9
Modulation of the antigenic phenotype of early-passage human melanoma cells derived from multiple autologous metastases by recombinant human leukocyte, fibroblast and immune interferon.重组人白细胞、成纤维细胞及免疫干扰素对源自多个自体转移灶的早期传代人黑素瘤细胞抗原表型的调节作用
Int J Cancer. 1990 Sep 15;46(3):539-45. doi: 10.1002/ijc.2910460334.
10
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