根据英国医学研究委员会1980 - 1984年UKALL VIII研究和试验进行治疗的两岁以下儿童（代表英国医学研究委员会儿童白血病工作组）。
Children under two years treated according to the Medical Research Council UKALL VIII study and trial 1980-1984 (on behalf of the Medical Research Council Working Party on Leukaemia in Childhood).
作者信息
Eden O B, Shaw M P, Lilleyman J S, Richards S
机构信息
Royal Hospital for Sick Children, Edinburgh, UK.
出版信息
Br J Cancer Suppl. 1992 Aug;18:S58-62.
Ten per cent of children entered into the national leukaemia study UKALL VIII were under 2 years at diagnosis. The 6 year event-free survival of this cohort was 39%. Specific adverse features were age under 1 year, high initial white cell count and null cell ALL. Those with common ALL, WBC 10-50 x 10(9) 1-1 and especially those aged 18 months or older did not have an adverse prognosis compared with the whole trial entrants. Overall, however there was a doubling of CNS relapse rate and of both induction and remission deaths. Those with a WBC under 10 x 10(9) 1-1 had a high haematological relapse rate. The type of leukaemia and method of management rather than specifically the age appeared to be the predictor for poor outcome.
参加英国儿童急性淋巴细胞白血病第八项全国性研究（UKALL VIII）的儿童中，10%在确诊时年龄不到2岁。该队列的6年无事件生存率为39%。特定的不良特征包括1岁以下、初始白细胞计数高以及无细胞急性淋巴细胞白血病。与整个试验参与者相比，患有普通急性淋巴细胞白血病、白细胞计数为10 - 50×10⁹/L且年龄在18个月及以上的患者预后并无不良。然而总体而言，中枢神经系统复发率以及诱导期和缓解期死亡率都增加了一倍。白细胞计数低于10×10⁹/L的患者血液学复发率较高。白血病类型和治疗方法而非特定年龄似乎是预后不良的预测因素。
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