Johnson F L, Rubin C M
Section of Pediatric Hematology/Oncology, University of Chicago Medical Center, Illinois 60637.
Br J Cancer Suppl. 1992 Aug;18:S76-9.
Marrow transplantation in infants with cancer present special challenges particularly because of the need to use conditioning regimens containing cytotoxic agents during a period of rapid somatic growth. An up-date of the largest study in children under 2 years of age treated by marrow transplantation for acute myeloblastic leukaemia, and a review of late effects experienced by older children, demonstrate the necessity to develop conditioning regimens which avoid total body radiation. Efforts to achieve this aim in the treatment of leukaemia are summarised.
癌症患儿的骨髓移植面临特殊挑战，尤其是在快速身体生长阶段需要使用含细胞毒性药物的预处理方案。一项针对2岁以下急性髓细胞白血病患儿接受骨髓移植的最大规模研究的最新情况，以及对大龄儿童晚期效应的综述，表明有必要制定避免全身放疗的预处理方案。本文总结了在白血病治疗中为实现这一目标所做的努力。
