用于水不溶性药物控释的单室渗透泵片
[Unitary-core osmotic pump tablet for controlled release of water-insoluble drug].
作者信息
Liu Long-xiao, Xu Qing, Khang Gilson, Rhee John-moon, Lee Hai-bang
机构信息
College of Pharmaceutical Science, Zhejiang University, Hangzhou 310027, China.
出版信息
Yao Xue Xue Bao. 2003 Dec;38(12):966-7.
AIM
To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours.
METHODS
Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied.
RESULTS
Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release.
CONCLUSION
Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.
目的
研究用于递送水不溶性药物达24小时的单室渗透泵片。
方法
以硝苯地平为模型药物制备单室渗透泵片。研究了各种片芯处方变量对药物释放的影响。
结果
聚环氧乙烷和氯化钾对药物释放有相当的积极作用，而硝苯地平对药物释放有明显的消极作用。
结论
单室渗透泵片制备非常简便，且能以基本恒定的速率递送水不溶性药物达24小时。
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