Praefcke Gerrit J K, McMahon Harvey T
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47. doi: 10.1038/nrm1313.
Dynamins are large GTPases that belong to a protein superfamily that, in eukaryotic cells, includes classical dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and guanylate-binding proteins/atlastins. They are involved in many processes including budding of transport vesicles, division of organelles, cytokinesis and pathogen resistance. With sequenced genomes from Homo sapiens, Drosophila melanogaster, Caenorhabditis elegans, yeast species and Arabidopsis thaliana, we now have a complete picture of the members of the dynamin superfamily from different organisms. Here, we review the superfamily of dynamins and their related proteins, and propose that a common mechanism leading to membrane tubulation and/or fission could encompass their many varied functions.
发动蛋白是一类大型GTP酶，属于一个蛋白质超家族，在真核细胞中，该超家族包括经典发动蛋白、发动蛋白样蛋白、OPA1、Mx蛋白、线粒体融合蛋白和鸟苷酸结合蛋白/atlastin。它们参与许多过程，包括运输小泡的出芽、细胞器的分裂、胞质分裂和病原体抗性。随着人类、黑腹果蝇、秀丽隐杆线虫、酵母物种和拟南芥的基因组测序完成，我们现在对来自不同生物体的发动蛋白超家族成员有了完整的了解。在这里，我们综述了发动蛋白及其相关蛋白的超家族，并提出导致膜成管和/或裂变的共同机制可能涵盖它们的多种功能。
