Kivrakidou Olga, Bräse Stefan, Hülshorst Frank, Griebenow Nils
Bayer AG, Bayer Health Care, Pharma Research, Building 460, D-42096 Wuppertal, Germany.
Org Lett. 2004 Apr 1;6(7):1143-6. doi: 10.1021/ol0498848.
The combinatorial synthesis of novel biphenyl tetrazoles is described. Key steps include the simultaneous biphenyl formation and phenol deallylation under Suzuki cross-coupling conditions as well as the tetrazole ring formation on solid support. A representative library of 20 biphenyl tetrazoles was synthesized.
描述了新型联苯四唑的组合合成。关键步骤包括在铃木交叉偶联条件下同时形成联苯和使苯酚脱烯丙基，以及在固体载体上形成四唑环。合成了一个包含20种联苯四唑的代表性文库。
