非洲常染色体STR数据库（AmpF/STR Identifiler和Powerplex 16系统）的贡献及基因型变异报告
Contribution for an African autosomic STR database (AmpF/STR Identifiler and Powerplex 16 System) and a report on genotypic variations.
作者信息
Alves Cíntia, Gusmão Leonor, Damasceno Albertino, Soares Benilde, Amorim António
机构信息
Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
出版信息
Forensic Sci Int. 2004 Jan 28;139(2-3):201-5. doi: 10.1016/j.forsciint.2003.11.002.
Allele frequencies, together with some parameters of forensic interest, for 17 STRs included in the AmpF/STR Identifiler (CSF1PO, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, FGA, TH01, TPO and VWA) and Powerplex 16 System (CSF1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, Penta D, Penta E, TH01, TPO and VWA) were estimated from a sample of 135-144 unrelated individuals from Mozambique. No deviations from Hardy-Weinberg equilibrium were observed with the exception of the FGA locus (using the Bonferroni correction for the number of loci analysed, the departure observed at this locus was not significant). Comparative analyses between our population data and other African databases, namely Promega's African-Americans, AB Applied Biosystems African-Americans and two other population samples from Mozambique and Guiné Bissau, are presented and discussed. Genotype inconsistencies between both commercial kits (for D16S539 and D8S1179) and other genotypic variations (three-banded allele patterns for TPO) are also reported.
从莫桑比克135 - 144名无亲缘关系个体的样本中估计了AmpF/STR Identifiler（CSF1PO、D2S1338、D3S1358、D5S818、D7S820、D8S1179、D13S317、D16S539、D18S51、D19S433、D21S11、FGA、TH01、TPO和VWA）和Powerplex 16系统（CSF1PO、D3S1358、D5S818、D7S820、D8S1179、D13S317、D16S539、D18S51、D21S11、FGA、五聚体D、五聚体E、TH01、TPO和VWA）中17个短串联重复序列（STR）的等位基因频率以及一些法医学相关参数。除FGA基因座外，未观察到偏离哈迪 - 温伯格平衡的情况（使用针对所分析基因座数量的邦费罗尼校正，该基因座观察到的偏离不显著）。展示并讨论了我们的群体数据与其他非洲数据库（即Promega公司的非裔美国人数据库、AB Applied Biosystems公司的非裔美国人数据库以及来自莫桑比克和几内亚比绍的另外两个群体样本）之间的比较分析。还报告了两种商业试剂盒之间的基因型不一致情况（针对D16S539和D8S1179）以及其他基因型变异（TPO的三带等位基因模式）。
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