环孢素的早期经验：历史视角
Early experience with cyclosporine: a historic perspective.
作者信息
Kostakis A
机构信息
2nd Department of Propedeutic Surgery, Athens University, Medical School, Laiko General Hospital, Athens, Greece.
出版信息
Transplant Proc. 2004 Mar;36(2 Suppl):22S-24S. doi: 10.1016/j.transproceed.2004.01.066.
Cyclosporine, a new antilymphocyte peptide, was tested in heterotopic heart transplantation between two different strains of rats. Prolongation of rat heart allograft survival was observed in treated hosts as compared with untreated controls (P<.001). These pioneering studies in pedicle animal grafts proved that cyclosporine is an extremely potent immunosuppressive drug. Its ability to suppress allograft rejection episodes could be applied to other species of animals and to humans.
环孢素，一种新型抗淋巴细胞肽，在两种不同品系大鼠之间的异位心脏移植中进行了测试。与未治疗的对照组相比，在接受治疗的宿主中观察到大鼠心脏同种异体移植存活时间延长（P<0.001）。这些在带蒂动物移植物方面的开创性研究证明，环孢素是一种极其有效的免疫抑制药物。其抑制同种异体移植排斥反应的能力可应用于其他动物物种和人类。
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