Velanovich Vic, Ezzat Waleed, Horn Christopher, Bernabei Alvise
Division of General Surgery, Henry Ford Hospital, Detroit, MI 48202-2689, USA.
Am J Surg. 2004 Apr;187(4):501-4. doi: 10.1016/j.amjsurg.2003.12.035.
Heart and lung transplantation is an increasingly successful procedure. After transplant, these patients may need surgery for common diseases and for problems caused by immunosuppression. The purpose of this study was to determine surgical outcomes heart and lung transplant patients after transplantation.
All patients in the cardiopulmonary transplant registry were reviewed. Data collected included sex, age at transplantation, age at subsequent procedure, number and type of surgical procedures performed, number and type of postoperative complications, grade of complications (using the Clavien classification), and outcome (discharge to home, disabled, dead).
During a 15-year period, 222 (64%) of 345 heart or lung transplant patients underwent a surgical procedure. Seven hundred fifty-four procedures were performed (median 3 procedures/patient). Sixty-seven patients suffered 72 complications (10% complication rate). Twenty-one (29%) complications were grade I; 20 (28%) were grade IIA; 21 (29%) were grade IIB; 8 (11%) were grade III; and 2 (3%) were grade IV. Twelve percent of the complications in the heart transplant patients were cardiac in nature, whereas 0% of the complications in the lung transplant patients were pulmonary in nature. There were 475 (63%) discharges to home, 2 (0.2%) inpatient deaths, and 18 (2%) deaths within 30 days; 49 (7%) procedures resulted in disability; and 210 (28%) patients were lost to follow-up.
Heart or lung transplant patients will frequently need subsequent surgical procedures. Overall, the patients tolerated the procedures well, and the morbidity and mortality rates were acceptable. Most complications were not related to the transplanted organ.
心肺移植是一种越来越成功的手术。移植后,这些患者可能需要因常见疾病以及免疫抑制引起的问题而接受手术。本研究的目的是确定心肺移植患者移植后的手术结果。
对心肺移植登记处的所有患者进行了回顾。收集的数据包括性别、移植时年龄、后续手术时年龄、所进行的手术程序数量和类型、术后并发症数量和类型、并发症分级(使用Clavien分类法)以及结果(出院回家、残疾、死亡)。
在15年期间,345例心肺移植患者中有222例(64%)接受了手术。共进行了754例手术(中位数为每位患者3例)。67例患者出现了72例并发症(并发症发生率为10%)。21例(29%)并发症为I级;20例(28%)为IIA级;21例(29%)为IIB级;8例(11%)为III级;2例(3%)为IV级。心脏移植患者中12%的并发症本质上是心脏性的,而肺移植患者中0%的并发症本质上是肺部性的。有475例(63%)患者出院回家,2例(0.2%)住院死亡,30天内有18例(2%)死亡;49例(7%)手术导致残疾;210例(28%)患者失访。
心肺移植患者经常需要后续手术。总体而言,患者对手术耐受性良好,发病率和死亡率是可接受的。大多数并发症与移植器官无关。