Guan Hong-mei, Wang Hui-li, Wei Xue
Department of Hematology, Second People's Hospital of Nanyang, Nanyang 473000, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Mar;24(3):343-4.
To explore the therapeutic effect of partial splenic embolization of different embolized volumes for idiopathic thrombocytopenic purpura (ITP) and consequent changes of the splenic function.
Forty-five ITP patients were randomized into 2 groups to receive splenic embolization with gelatin sponge particles, and the embolized volume ranged between 60% and 80% in the former group (group A), and between 40% and 60% in the latter group (group B).
The platelet counts of the patients in both groups markedly increased one week after the operation, and the average count was significant higher in group A than in group B one year after the operation (P<0.01). The splenic function of the patients in neither of groups underwent any significant changes after the operation (P>0.05).
Splenic embolization of different volumes produces similar therapeutic effect on ITP, but more extensive embolization may insure long-lasting effect with better safety and less influence on splenic function.
