Wang Zhi-gang, Huang Yi-dong, Cheng Ke-luo, Cai Xiao-bi, Wu Zheng, Zhan Jian-dong
Department of Cardiothoracic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Mar;24(3):345-6, 351.
To study how blood supply of the esophageal and gastric stumps influences the anastomotic healing after esophagogastrostomy in rabbits.
Twenty-seven New Zealand rabbits were randomly divided into 3 groups to receive esophagogastrostomy, followed by different procedures. Except for those in group I, all the rabbits were subjected to procedures of reducing the blood supply either of the esophageal or the gastric stump (group II and group III, respectively), followed by single-layer esophagogastric anastomoses using interrupted 5-0 polypropylene sutures. Ten days after operation, all the rats were killed and the anastomotic sites excised for measurement of the inner diameter, tensile strength, and hydroxyproline concentration.
Healing of the esophagograstric anastomosis was obtained in all the rabbits but one with anastomotic leakage in group I and one with perforation of the gastric fundus in group III. The anastomotic inner diameters were similar in all the three groups, whereas the tensile strength and hydroxyproline concentration at the anastomoses decreased in group III in comparison with the other two groups (P<0.05) that had similar measurements (P>0.05).
Extended length of the free esophageal stump does not significantly affect anastomotic healing as decrease of blood supply in the gastric stump.
研究食管和胃残端的血供如何影响兔食管胃吻合术后的吻合口愈合。
将27只新西兰兔随机分为3组进行食管胃吻合术，然后采取不同的操作。除I组外，所有兔子均接受减少食管或胃残端血供的操作（分别为II组和III组），随后用5-0聚丙烯间断缝线进行单层食管胃吻合。术后10天，处死所有大鼠，切除吻合部位，测量内径、抗张强度和羟脯氨酸浓度。
所有兔子均实现食管胃吻合口愈合，但I组有1只出现吻合口漏，III组有1只胃底穿孔。三组的吻合口内径相似，而III组吻合口的抗张强度和羟脯氨酸浓度低于其他两组（P<0.05），后两组的测量结果相似（P>0.05）。
游离食管残端长度的延长对吻合口愈合的影响不如胃残端血供减少显著。
