多胎妊娠中白细胞介素-4和-10基因多态性与自发性早产

Interleukin-4 and -10 gene polymorphisms and spontaneous preterm birth in multifetal gestations.

作者信息

Kalish Robin B, Vardhana Santosh, Gupta Meruka, Perni Sriram C, Witkin Steven S

机构信息

Department of Obstetrics and Gynecology, the Divisions of Maternal-Fetal Medicine and Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA.

出版信息

Am J Obstet Gynecol. 2004 Mar;190(3):702-6. doi: 10.1016/j.ajog.2003.09.066.

DOI:10.1016/j.ajog.2003.09.066

PMID:15042002

Abstract

OBJECTIVE

The purpose of this study was to determine the relationship between maternal and fetal carriage of different alleles of interleukin-4 and -10 genes and pregnancy outcome in multifetal gestations.

STUDY DESIGN

Buccal swabs from mother-infant pairs of 73 multifetal gestations were assayed for polymorphisms at position -590 of the interleukin-4 gene and position -1082 of the interleukin-10 gene. Pregnancy outcome data were obtained subsequently.

RESULTS

Spontaneous preterm birth occurred in 29 of the pregnancies (39.7%). A higher frequency of the interleukin-4 T allele was found among mothers with spontaneous preterm birth compared with mothers without spontaneous preterm birth (36.2% vs 18.2%; P=.02; odds ratio, 2.6; 95% CI, 1.1-5.9). Moreover, 20.7% of mothers who had spontaneous preterm birth were homozygous for the interleukin-4 T allele, as opposed to only 2.3% of mothers who did not have a spontaneous preterm birth (P=.01; odds ratio, 11.2; 95% CI, 1.2-69.5). Similarly, in 55.2% of the pregnancies that were complicated by spontaneous preterm birth, 2 fetuses carried the interleukin-4 T allele, compared with only 29.5% of the pregnancies that were not complicated by spontaneous preterm birth (p<.05; odds ratio, 2.9; 95% CI, 1.0-8.8). There was no relationship between mother and infant IL-10 genotype and spontaneous preterm birth.

CONCLUSION

Maternal and fetal carriage of the interleukin-4 T allele is associated with an increased risk of spontaneous preterm birth in multifetal gestations.

摘要

目的

本研究旨在确定白细胞介素-4和-10基因不同等位基因的母婴携带情况与多胎妊娠结局之间的关系。

研究设计

对73例多胎妊娠母婴对的口腔拭子进行白细胞介素-4基因-590位点和白细胞介素-10基因-1082位点的多态性检测。随后获取妊娠结局数据。

结果

29例妊娠（39.7%）发生自发性早产。与未发生自发性早产的母亲相比，发生自发性早产的母亲中白细胞介素-4 T等位基因的频率更高（36.2%对18.2%；P = 0.02；优势比，2.6；95%可信区间，1.1 - 5.9）。此外，发生自发性早产的母亲中有20.7%为白细胞介素-4 T等位基因纯合子，而未发生自发性早产的母亲中仅为2.3%（P = 0.01；优势比，11.2；95%可信区间，1.2 - 69.5）。同样，在55.2%并发自发性早产的妊娠中，有2个胎儿携带白细胞介素-4 T等位基因，而未并发自发性早产的妊娠中这一比例仅为29.5%（p<0.05；优势比，2.9；95%可信区间，1.0 - 8.8）。母婴白细胞介素-10基因型与自发性早产之间无关联。