Malina Amanda N, Laivuori Hannele M, Agatisa Patricia K, Collura Lynn A, Crombleholme William R, Sims Cynthia J, Roberts James M
Magee-Womens Research Institute and Department of Obstetrics, University of Pittsburgh, Pittsburgh, PA, USA.
Am J Obstet Gynecol. 2004 Mar;190(3):779-83. doi: 10.1016/j.ajog.2003.09.026.
Insulin resistance is greater and obesity is more common in women with preeclampsia. The Trp64Arg polymorphism in the beta(3)-adrenergic receptor is associated with these metabolic changes. This study investigated whether the Trp64Arg polymorphism is more common in women with preeclampsia.
beta(3)-Adrenergic receptor genotypes were determined in 177 women with a history of preeclampsia and in 179 normal pregnancies. We also compared prepregnancy body mass index (BMI), length of gestation, baby weight percentile, and glucose values during an oral tolerance test in women with and without the polymorphism.
The genotypes and allele frequency did not differ significantly between women with preeclamptic and normal pregnancies (P=.17). Women with and without the polymorphism had similar prepregnancy BMI, glucose at 1-hour screening, gestational age at delivery, and adjusted baby weight.
The Trp64Arg polymorphism of the beta(3)-receptor does not predispose to preeclampsia, and it is it not associated with obesity and carbohydrate intolerance in a population of young pregnant women.
子痫前期女性的胰岛素抵抗更严重，肥胖也更常见。β(3)-肾上腺素能受体中的色氨酸64精氨酸多态性与这些代谢变化相关。本研究调查了色氨酸64精氨酸多态性在子痫前期女性中是否更常见。
对177例有子痫前期病史的女性和179例正常妊娠女性测定β(3)-肾上腺素能受体基因型。我们还比较了有或没有该多态性的女性孕前体重指数（BMI）、妊娠时长、婴儿体重百分位数以及口服糖耐量试验期间的血糖值。
子痫前期女性和正常妊娠女性的基因型及等位基因频率无显著差异（P = 0.17）。有或没有该多态性的女性孕前BMI、1小时筛查血糖、分娩时孕周以及校正后的婴儿体重相似。
β(3)-受体的色氨酸64精氨酸多态性不会诱发子痫前期，在年轻孕妇群体中也与肥胖和碳水化合物不耐受无关。
