Sípek A, Gregor V, Horácek J, Masátová D
Ustav pro péci o matku a dítĕ, Institut postgraduálního vzdĕlávání ve zdravotnictví, Katedra gynekologicko-porodnická, Praha.
Ceska Gynekol. 2003 Nov;68(6):389-94.
Analysis of the proportion of selected types of congenital defects in stillbirth, frequent neonatal and perinatal death rate in the Czech Republic in the years 1994-2002.
A retrospective demographic-epidemiological analysis.
Institute for the Care of Mother and Child, Prague.
The study analyzed individual anonymous data from the Institute of Medical Information and Statistics of the Czech Republic in the period of 1994-2002 (preliminary data only for 2002) from the National Registry of Congental Defects. Fourteen types of defects were selected from the data set. The proportion of children with a certain selected congenital defect which died during the perinatal period were calculated in comparison with the total number of subjects diagnosed for this congential defect in the Czech Republic over the period of observation.
A total of 4,436 children died during the perinatal period in the Czech Republic over the period of 1994-2002, while 879 of them suffered from one or more congenital defects. The congenital defects represent more than 10% of stillbirth in this period, 32.5% of deceased individuals in early neonatal death rate and almost 20% in perinatal death rate. In 25% of these cases the prenatal diagnosis was positive, whereas prenatal diagnosis was negative or not indicated (a negative screening) in 48% of cases, and in 27% the data were not filled out. More than 45% of children deceased with a congenital defect in the perinatal period had two or more congenital defects.
Analysis of these results from the registry of congenital defects in the Czech Republic contributed to the information on prenatal deaths in the period of 1994-2002. The proportion of congenital defects in perinatal death rate makes up almost 20%, but it also significantly participates in late newborn and post-newborn mortality and morbidity.
分析1994 - 2002年捷克共和国死产中特定类型先天性缺陷的比例、新生儿和围产期频繁死亡率。
回顾性人口统计学 - 流行病学分析。
布拉格母婴护理研究所。
该研究分析了捷克共和国医学信息与统计研究所1994 - 2002年期间（仅2002年为初步数据）来自国家先天性缺陷登记处的个体匿名数据。从数据集中选取了14种缺陷类型。计算了在围产期死亡的患有某种选定先天性缺陷的儿童比例，并与观察期内捷克共和国诊断出该先天性缺陷的受试者总数进行比较。
1994 - 2002年期间，捷克共和国共有4436名儿童在围产期死亡，其中879名患有一种或多种先天性缺陷。先天性缺陷在此期间占死产的10%以上，在早期新生儿死亡率中占死亡个体的32.5%，在围产期死亡率中占近20%。在这些病例中，25%的产前诊断为阳性，而48%的病例产前诊断为阴性或未进行（阴性筛查），27%的数据未填写。围产期因先天性缺陷死亡的儿童中，超过45%患有两种或更多种先天性缺陷。
对捷克共和国先天性缺陷登记处的这些结果进行分析，有助于了解1994 - 2002年期间的产前死亡情况。先天性缺陷在围产期死亡率中所占比例近20%，但它也显著影响晚期新生儿和新生儿后期的死亡率和发病率。
