Pilka R, Dzvincuk P, Kudela M
Gynekologicko-porodnická klinika LF UP a FN Olomouc.
Ceska Gynekol. 2003 Nov;68(6):427-31.
To summarise recent knowledge about lymphangiogenesis, markers of the lymphatic endothelium and their importance to the tumor dissemination.
A literature review.
Department of Gynecology and Obstetrics, Medical Faculty, Palacký University, University Hospital, Olomouc.
Clinicopathological data suggest that the lymphatics are an initial route for the spread of solid tumors. Detection of sentinel lymph nodes by biopsy provides significant information for staging and designing therapeutic regimens. The role of angiogenesis (formation of new blood vessels) in facilitating the growth of tumors has been well established, but the presence of lymphatic vessels and the relevance of lymphangiogenesis (formation of new lymphatics) to tumor spread are less clear. Growth factors involved in lymphangiogenesis during embryogenesis have been recently identified and showed to be able to induce formation of intratumoral lymphatics and thus facilitate metastatic spread to lymph nodes. The development of approaches to block tumor lymphangiogenesis and treat lymphedema would benefit from the availability of markers specific for lymphatic endothelium.
总结近期关于淋巴管生成、淋巴管内皮标志物及其对肿瘤播散重要性的知识。
文献综述。
奥洛穆茨帕拉茨基大学医学院大学医院妇产科。
临床病理数据表明，淋巴管是实体瘤播散的初始途径。通过活检检测前哨淋巴结可为肿瘤分期和制定治疗方案提供重要信息。血管生成（新血管形成）在促进肿瘤生长中的作用已得到充分证实，但淋巴管的存在以及淋巴管生成（新淋巴管形成）与肿瘤播散的相关性尚不清楚。最近已鉴定出胚胎发育过程中参与淋巴管生成的生长因子，这些因子能够诱导肿瘤内淋巴管的形成，从而促进肿瘤向淋巴结的转移扩散。开发阻断肿瘤淋巴管生成和治疗淋巴水肿的方法将受益于淋巴管内皮特异性标志物的可用性。
