Perlin David S
Public Health Research Institute, International Center for Public Health, 225 Warren Street, Newark, NJ 07103, USA.
Curr Opin Investig Drugs. 2004 Feb;5(2):198-201.
Cochleates are a novel lipid-based delivery vehicle consisting of crystalline phospholipid-cation structures that form spiral lipid sheets. They represent a new technology platform for oral delivery of clinically important drugs that possess poor oral bioavailability. Orally administered cochleates containing amphotericin B (CAMB) showed broad-spectrum activity in murine infection models of candidiasis, aspergillosis and cryptococcosis. Initial biodistribution studies of CAMB administered orally in mice demonstrated that cochleates delivered significant levels of AMB to target organs. The lipid particulate nature of cochleates also imparted reduced toxicity that mimics other lipid-amphotericin B complexes. Cochleates are a promising new vehicle for oral delivery of amphotericin B at therapeutic levels.
耳蜗形脂质体是一种新型的基于脂质的给药载体，由形成螺旋脂质片的结晶磷脂 - 阳离子结构组成。它们代表了一种新技术平台，用于口服递送口服生物利用度差的临床重要药物。口服含两性霉素B的耳蜗形脂质体（CAMB）在念珠菌病、曲霉病和隐球菌病的小鼠感染模型中显示出广谱活性。对口服给予小鼠的CAMB进行的初步生物分布研究表明，耳蜗形脂质体将大量的两性霉素B递送至靶器官。耳蜗形脂质体的脂质颗粒性质还降低了毒性，这与其他脂质 - 两性霉素B复合物类似。耳蜗形脂质体是一种有前景的新型载体，可用于以治疗水平口服递送两性霉素B。
