Nakamura Yuko, Nakamura Yoshimi, Morine-Shinjo Sayo, Sakai Hiroshi, Sawaguchi Shoichi
Department of Ophthalmology, Ryukyu University, Faculty of Medicine, Okinawa, Japan.
Acta Ophthalmol Scand. 2004 Apr;82(2):158-60. doi: 10.1111/j.1600-0420.2004.00243.x.
This study aimed to determine whether the longterm use of latanoprost is associated with an increase in trabecular pigmentation, especially in subjects in whom iris pigmentation has increased.
We enrolled 50 subjects for whom treatment was to start for ocular hypertension, primary open-angle glaucoma or normal tension glaucoma. All subjects received latanoprost 0.005% daily. Trabecular pigmentation was documented using gonioscopic photography of the inferior quadrant at baseline, every 3 months for the first year and every 6 months for the second and third years. Three glaucoma specialists evaluated the series of gonioscopic photographs for each eye of each subject in a masked fashion. The intraocular pressure (IOP) was also recorded at each visit.
A total of 41 subjects (79 eyes) completed 3 years of follow-up, and none showed any increase in the grade of trabecular pigmentation, including 10 subjects (20 eyes) in whom the iridial pigment increased.
Although latanoprost increased iridial pigmentation in some subjects, we found no evidence of an increase in trabecular pigmentation over the 3 years of follow-up.
本研究旨在确定长期使用拉坦前列素是否与小梁色素沉着增加有关，尤其是在虹膜色素沉着增加的受试者中。
我们招募了50名因高眼压症、原发性开角型青光眼或正常眼压性青光眼而即将开始治疗的受试者。所有受试者每天使用0.005%的拉坦前列素。在基线时、第一年每3个月以及第二年和第三年每6个月，使用下象限房角镜摄影记录小梁色素沉着情况。三位青光眼专家以盲法评估每个受试者每只眼睛的一系列房角镜照片。每次就诊时还记录眼压（IOP）。
共有41名受试者（79只眼）完成了3年的随访，且无一例小梁色素沉着等级增加，其中包括10名（20只眼）虹膜色素增加的受试者。
尽管拉坦前列素在一些受试者中增加了虹膜色素沉着，但在3年的随访中，我们未发现小梁色素沉着增加的证据。
