Kumar Atul, Prakash Gunjan, Singh Rajindra P
Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Acta Ophthalmol Scand. 2004 Apr;82(2):205-8. doi: 10.1046/j.1600-0420.2004.00217.x.
To assess the efficacy of transpupillary thermotherapy (TTT) for the management of idiopathic subfoveal choroidal neovascularization (CNV).
This was a prospective, non-controlled, clinical case trial involving 21 eyes of 21 patients with a mean age of 36 years. All 21 eyes had idiopathic subfoveal CNV and were subjected to diode laser TTT. Laser beam size ranged from 1.2 mm to 3.0 mm and power settings ranged between 300 mW and 600 mW. The end-point was an area of no visible colour change. Pre- and post-laser evaluations of ETDRS visual acuity, contrast sensitivity, slit-lamp biomicroscopy and fluorescein angiography were carried out.
The nine predominantly occult and 12 predominantly classic subfoveal membranes were followed-up for a mean of 5.1 months after TTT. Overall, 17 eyes (81%) showed improvement or stabilization in ETDRS visual acuity. Contrast sensitivity improved in 17 eyes (81%). Reading speed improved in 15 eyes (71%). Retreatment was needed in three eyes (14%).
Transpupillary thermotherapy treatment is a potential strategy for treating idiopathic subfoveal CNV in both its classic and occult forms.
评估经瞳孔温热疗法（TTT）治疗特发性黄斑下脉络膜新生血管（CNV）的疗效。
这是一项前瞻性、非对照临床病例试验，纳入21例患者的21只眼，平均年龄36岁。所有21只眼均患有特发性黄斑下CNV，并接受二极管激光TTT治疗。激光束大小范围为1.2毫米至3.0毫米，功率设置范围为300毫瓦至600毫瓦。终点为无可见颜色变化的区域。在激光治疗前后进行ETDRS视力、对比敏感度、裂隙灯生物显微镜检查和荧光素血管造影评估。
9只主要为隐匿性和12只主要为典型性的黄斑下膜在TTT后平均随访5.1个月。总体而言，17只眼（81%）的ETDRS视力有所改善或稳定。17只眼（81%）的对比敏感度有所提高。15只眼（71%）的阅读速度有所提高。3只眼（14%）需要再次治疗。
经瞳孔温热疗法是治疗典型和隐匿型特发性黄斑下CNV的一种潜在策略。
