Gomi T, Ikeda T, Harano T
Department of Nephrology, Kanto-Teishin Hospital, Tokyo, Japan.
Intern Med. 1992 May;31(5):659-61. doi: 10.2169/internalmedicine.31.659.
Hemoglobin Andrew-Minneapolis, an abnormal hemoglobin with an asparagine residue substituted for a lysine at position 144 of the beta-globulin chains, was identified in three members of two generations in a Japanese family. The carriers of hemoglobin Andrew-Minneapolis showed false high levels of hemoglobin A1c, as measured by the standard cation exchange high performance liquid chromatography, and a moderate tendency for erythrocytosis. This family is the first report of this abnormal hemoglobin in Japan.
安德鲁 - 明尼阿波利斯血红蛋白，一种异常血红蛋白，在β - 球蛋白链的第144位赖氨酸被天冬酰胺残基取代，在一个日本家庭的两代人中的三名成员中被发现。通过标准阳离子交换高效液相色谱法测量，安德鲁 - 明尼阿波利斯血红蛋白的携带者显示血红蛋白A1c水平假性升高，并有中度红细胞增多倾向。该家族是日本首次报道的这种异常血红蛋白。
