化疗药物卡莫司汀（BCNU）细胞耐药性的体外分析。
In vitro analysis of the cellular resistance to chemotherapeutic BCNU.
作者信息
Caballero Navarro A, Conde Guerri B, Sinues Porta E, Boada Apilluelo E, Alcalá Arellano A
机构信息
Department of Physiatry and Nursery, Faculty of Medicine, University of Zaragoza, Spain.
出版信息
Histol Histopathol. 1992 Jul;7(3):347-51.
Our assays in vitro show that BCNU inhibits cell proliferation in the C6 cell line experimental glioma and is dose-dependent, starting from 0.5 microgram/ml of the drug with just an hour of exposure. For every tested concentration of BCNU it is shown that, from the fifth day after exposure, cellular resistance appeared. This resistance is justified by the capacity of cell DNA reparation. A study of the clonogenic capacity of the C6 cells exposed to BCNU also shows the appearance of cellular resistance for doses of 0.5 microgram/ml and 1 microgram/ml. Furthermore, the exposure of C6 cell cultures to BCNU at these levels produces a cellular evolution towards more differentiated morphological patterns.
我们的体外试验表明，卡莫司汀（BCNU）可抑制C6细胞系实验性胶质瘤的细胞增殖，且具有剂量依赖性，从药物浓度为0.5微克/毫升且仅暴露一小时开始。对于每个测试的BCNU浓度，结果显示，在暴露后的第五天出现细胞抗性。这种抗性可通过细胞DNA修复能力来解释。对暴露于BCNU的C6细胞的克隆形成能力的研究还表明，在剂量为0.5微克/毫升和1微克/毫升时出现细胞抗性。此外，将C6细胞培养物暴露于这些水平的BCNU会使细胞向更分化的形态模式演变。
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