Heude Barbara, Dubois Séverine, Charles Marie-Aline, Deweirder Marianne, Dina Christian, Borys Jean-Michel, Ducimetière Pierre, Froguel Philippe
Institut National de la Santé Et de la Recherche Médicale, Unité 258-IFR69, Faculté de Médecine Paris Sud, Villejuif, France.
Obes Res. 2004 Mar;12(3):499-504. doi: 10.1038/oby.2004.56.
The VNTR polymorphism 5' of the insulin gene has been related to obesity in a previous study on children with early onset of severe obesity. Our purpose was to analyze the association between this polymorphism and adiposity variability in an unselected population of children and adolescents in northern France.
In 293 nuclear families from the Fleurbaix Laventie Ville Santé study, we genotyped the INS VNTR polymorphism in 431 children and adolescents (8 to 18 years of age) and their parents. Overweight was defined according to the international definition in both children and adults. A transmission disequilibrium test in families with an overweight offspring was performed. The prevalence of overweight was compared according to genotype. The effect of the genotype on BMI and waist circumference was tested with a linear regression model, adjusting for age, gender, and Tanner stage.
There was an undertransmission of class III alleles from heterozygous parents to their overweight offspring (p < 0.002). Overweight was associated with class I alleles in children and adolescents (12% I/I, I/III vs. 3% III/III; p < 0.08). Those with a class III/III genotype had a 1 kg/m(2) lower mean BMI (p = 0.04) and 3 cm lower waist circumference (p = 0.02) than those bearing one or two class I alleles. No association of adiposity or obesity with class I alleles was found in parents.
INS VNTR polymorphism seems to contribute to differences in adiposity level in the general population of children and adolescents.
在先前一项针对早发性严重肥胖儿童的研究中，胰岛素基因5'端可变数目串联重复序列（VNTR）多态性已被证明与肥胖有关。我们的目的是分析在法国北部一个未经选择的儿童和青少年群体中，这种多态性与肥胖程度变化之间的关联。
在来自弗勒尔拜 - 拉旺蒂 - 维勒桑泰研究的293个核心家庭中，我们对431名儿童和青少年（8至18岁）及其父母进行了胰岛素基因VNTR多态性基因分型。超重按照国际定义在儿童和成人中进行界定。对有超重后代的家庭进行传递不平衡检验。根据基因型比较超重的患病率。使用线性回归模型检验基因型对体重指数（BMI）和腰围的影响，并对年龄、性别和坦纳分期进行校正。
III类等位基因从杂合子父母向超重后代的传递不足（p < 0.002）。儿童和青少年中超重与I类等位基因相关（I/I、I/III型为12%，III/III型为3%；p < 0.08）。与携带一个或两个I类等位基因的人相比，基因型为III/III型的人平均BMI低1 kg/m²（p = 0.04），腰围小3 cm（p = 0.02）。在父母中未发现肥胖或超重与I类等位基因有关联。
胰岛素基因VNTR多态性似乎导致了儿童和青少年总体人群中肥胖程度的差异。
