Michailov Galin V, Sereda Michael W, Brinkmann Bastian G, Fischer Tobias M, Haug Bernhard, Birchmeier Carmen, Role Lorna, Lai Cary, Schwab Markus H, Nave Klaus-Armin
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Science. 2004 Apr 30;304(5671):700-3. doi: 10.1126/science.1095862. Epub 2004 Mar 25.
In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells. Reduced Nrg1 expression causes hypomyelination and reduced nerve conduction velocity. Neuronal overexpression of Nrg1 induces hypermyelination and demonstrates that Nrg1 type III is the responsible isoform. We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size.
在脊椎动物的神经系统中，髓鞘形成对于快速且准确的冲动传导至关重要。髓鞘厚度取决于轴突纤维大小。我们利用突变和转基因小鼠品系来表明，轴突神经调节蛋白-1（Nrg1）向施万细胞传递有关轴突大小的信息。Nrg1表达降低会导致髓鞘形成不足和神经传导速度减慢。Nrg1在神经元中的过表达会诱导髓鞘过度形成，并表明Nrg1 III型是起作用的同种型。我们提出了一个模型，通过该模型，形成髓鞘的施万细胞将轴突Nrg1信号整合为轴突大小的生化指标。
