Frei Christian
Zoologisches Institut, University of Zürich, Switzerland.
Cell Cycle. 2004 May;3(5):558-60. Epub 2004 May 19.
The Drosophila cyclin-dependent protein kinase complex CycD/Cdk4 has been known to drive cellular growth (accumulation of mass) as well as proliferation (cell cycle progression). Recent data demonstrate that Hif prolyl hydroxylase (Hph) is required for the induction of growth, but not for the induction of proliferation. Normal levels of Hph are required for cellular growth, demonstrating that Hph, in addition to its known function in the cellular response low oxygen levels, regulates growth. Since Hph's hydroxylation activity depends on oxygen and possibly the mitochondrial activity, these data provide a link between CycD/Cdk4 and oxygen/energy homeostasis.
已知果蝇细胞周期蛋白依赖性蛋白激酶复合物CycD/Cdk4可驱动细胞生长（质量积累）以及增殖（细胞周期进程）。最近的数据表明，Hif脯氨酰羟化酶（Hph）是诱导生长所必需的，但不是诱导增殖所必需的。细胞生长需要正常水平的Hph，这表明Hph除了在细胞对低氧水平的反应中具有已知功能外，还调节生长。由于Hph的羟化活性取决于氧气以及可能的线粒体活性，这些数据提供了CycD/Cdk4与氧/能量稳态之间的联系。
