西甲硅油用于胶囊内镜检查的小肠准备：一项系统、单盲、对照研究。
Simethicone for small bowel preparation for capsule endoscopy: a systematic, single-blinded, controlled study.
作者信息
Albert Jörg, Göbel Christa-Maria, Lesske Joachim, Lotterer Erich, Nietsch Hubert, Fleig Wolfgang E
机构信息
First Department of Medicine, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany.
出版信息
Gastrointest Endosc. 2004 Apr;59(4):487-91. doi: 10.1016/s0016-5107(04)00003-3.
BACKGROUND
Capsule endoscopy is a new imaging method for visualization of the entire small bowel. However, no standardized protocol for bowel preparation for capsule endoscopy has been evaluated.
METHODS
Capsule endoscopy was performed in 36 consecutive patients, all of whom fasted for 12 hours before ingestion of the capsule. Before capsule endoscopy, 18 patients received 80 mg simethicone and 18 had no supplemental medication for bowel preparation. Two observers, both experienced endoscopists, independently reviewed the examinations in a single-blinded and randomly assigned fashion. Mucosal visibility and intraluminal gas bubbles were assessed and graded by both observers.
RESULTS
Bowel preparation with simethicone resulted in significantly better visibility because of fewer intraluminal bubbles (p<0.01). Interobserver agreement was excellent (r>/=0.8; k 0.78: 95% CI[0.57, 0.98] ). No adverse effect of simethicone was observed.
CONCLUSIONS
Simethicone may be added to the routine preparation for capsule endoscopy to improve the visibility of small bowel mucosa.
背景
胶囊内镜是一种用于观察整个小肠的新型成像方法。然而，尚未对胶囊内镜肠道准备的标准化方案进行评估。
方法
对36例连续患者进行胶囊内镜检查，所有患者在吞服胶囊前禁食12小时。在胶囊内镜检查前，18例患者服用80毫克西甲硅油，18例未进行肠道准备的补充用药。两名经验丰富的内镜医师以单盲、随机分配的方式独立回顾检查结果。两位观察者对黏膜可视性和腔内气泡进行评估和分级。
结果
西甲硅油肠道准备因腔内气泡较少，黏膜可视性显著更好（p<0.01）。观察者间一致性良好（r≥0.8；k 0.78：95%可信区间[0.57，0.98]）。未观察到西甲硅油的不良反应。
结论
西甲硅油可添加到胶囊内镜的常规准备中，以提高小肠黏膜的可视性。
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