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用奥曲肽成功治疗一名早产儿的自发性乳糜胸。

Successful treatment with octreotide of spontaneous chylothorax in a premature infant.

作者信息

Coulter David M

机构信息

Division of Neonatology, Department of Pediatrics, The University of Utah School of Medicine, Salt Lake City, UT 84132-2202, USA.

出版信息

J Perinatol. 2004 Mar;24(3):194-5. doi: 10.1038/sj.jp.7211031.

DOI:10.1038/sj.jp.7211031
PMID:15044931
Abstract

A 2-month-old premature infant developed a spontaneous chylothorax. Medical therapy (chest tube drainage, parenteral alimentation) and thoracic duct ligation at 103 days of age had no effect. Drainage ceased during an octreotide infusion. The effusion recurred after octreotide was stopped, and responded completely to a longer course of therapy. Octreotide offers a substantial advantage over current medical management to some babies with spontaneous chylothorax.

摘要

一名2个月大的早产儿发生了自发性乳糜胸。药物治疗(胸腔闭式引流、胃肠外营养)以及在103日龄时进行的胸导管结扎均无效。在注射奥曲肽期间胸腔引流停止。奥曲肽停用后积液复发,而在较长疗程的治疗后积液完全消退。对于一些患有自发性乳糜胸的婴儿,奥曲肽比目前的药物治疗具有显著优势。

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引用本文的文献

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Congenital Chylothorax of the Newborn: A Systematic Analysis of Published Cases between 1990 and 2018.新生儿先天性乳糜胸:1990 年至 2018 年发表病例的系统分析。
Respiration. 2022;101(1):84-96. doi: 10.1159/000518217. Epub 2021 Sep 1.
2
Unusual case of chylothorax with unilateral limb swelling.伴有单侧肢体肿胀的乳糜胸罕见病例。
BMJ Case Rep. 2020 Feb 10;13(2):e230379. doi: 10.1136/bcr-2019-230379.
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Evaluating the Use of Octreotide for Acquired Chylothorax in Pediatric Critically Ill Patients Following Cardiac Surgery.
评估奥曲肽在小儿心脏手术后重症患者获得性乳糜胸治疗中的应用。
J Pediatr Pharmacol Ther. 2019 Sep-Oct;24(5):406-415. doi: 10.5863/1551-6776-24.5.406.
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Safety of octreotide in hospitalized infants.奥曲肽在住院婴儿中的安全性。
Early Hum Dev. 2015 Jul;91(7):387-92. doi: 10.1016/j.earlhumdev.2015.04.008. Epub 2015 May 15.
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An unusual cause of recurrent chylothorax: gorham syndrome.复发性乳糜胸的一种罕见病因:戈勒姆综合征。
APSP J Case Rep. 2014 May 21;5(2):23. eCollection 2014 May.
6
Successful treatment of neonatal chylothorax with octreotide.奥曲肽成功治疗新生儿乳糜胸。
Indian J Pediatr. 2011 Nov;78(11):1412-4. doi: 10.1007/s12098-011-0486-x. Epub 2011 May 28.
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Somatostatin or octreotide as treatment options for chylothorax in young children: a systematic review.生长抑素或奥曲肽作为幼儿乳糜胸的治疗选择:一项系统评价
Intensive Care Med. 2006 May;32(5):650-7. doi: 10.1007/s00134-006-0114-9. Epub 2006 Mar 11.