Trask Andrew V, Motherwell W D Samuel, Jones William
Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Chem Commun (Camb). 2004 Apr 7(7):890-1. doi: 10.1039/b400978a. Epub 2004 Mar 5.
By grinding with a minimal addition of a solvent of appropriate polarity, control over the polymorphic outcome of a novel cocrystallisation involving the model pharmaceutical compound caffeine may be achieved.
通过在极少添加适当极性溶剂的情况下进行研磨，可以实现对涉及模型药物化合物咖啡因的新型共结晶多晶型结果的控制。
