Vanhaecke F, Riondato J, Moens L, Dams R
Laboratory of Analytical Chemistry, Institute for Nuclear Sciences, Ghent University, Proeftuinstraat 86, B-9000, Ghent, Belgium.
Anal Bioanal Chem. 1996 Jun;355(3-4):397-400. doi: 10.1007/s0021663550397.
Results of a systematic study concerning non-spectral interferences observed with a commercially available high resolution ICP-mass spectrometer are reported and compared to observations made with a quadrupole-based instrument. In general, matrix effects were observed to be to a large extent comparable for both instruments used. In all cases, the matrix-induced signal suppression or enhancement was seen to depend in a regular way on the mass number of the nuclides monitored. In most cases, the ionization potential of the nuclides has little or no influence on the extent of suppression or enhancement. For As, Se and Te, the introduction of 2.5% ethanol, 0.5 mol/l H(2)SO(4), or to a lesser extent 0.5 mol/l H(3)PO(4), leads to an exceptional increase in the signal intensity for both instruments. Registration of signal behaviour plots (signal intensity as a function of the nebulizer gas flow rate) in different matrices revealed that both the height of the plot and the optimum nebulizer gas flow rate are a function of the matrix composition. Finally, no indication was found that the acceleration of the extracted ions over 8000 V with the high resolution instrument would lead to an alleviation of space charge effects when compared to a quadrupole-based ICP-mass spectrometer.
报告了一项关于使用市售高分辨率电感耦合等离子体质谱仪观察到的非光谱干扰的系统研究结果，并将其与使用基于四极杆的仪器的观察结果进行了比较。一般来说，观察到两种仪器的基体效应在很大程度上是可比的。在所有情况下，基体诱导的信号抑制或增强都以一种规则的方式取决于所监测核素的质量数。在大多数情况下，核素的电离势对抑制或增强程度几乎没有影响。对于砷、硒和碲，引入2.5%的乙醇、0.5mol/L的硫酸或在较小程度上引入0.5mol/L的磷酸，会导致两种仪器的信号强度异常增加。在不同基体中记录信号行为图（信号强度作为雾化器气体流速的函数）表明，图的高度和最佳雾化器气体流速都是基体组成的函数。最后，没有发现迹象表明，与基于四极杆的电感耦合等离子体质谱仪相比，使用高分辨率仪器将提取离子加速超过8000V会减轻空间电荷效应。
