Nagasawa Eriko, Abe Yasunobu, Matsushima Takamitsu, Choi Ilseung, Tachikawa Yoshimichi, Ohtsuka Rie, Ishikura Hideki, Nishimura Junji, Inaba Shoichi, Nawata Hajime, Muta Koichiro
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
Rinsho Ketsueki. 2004 Feb;45(2):167-9.
We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.
我们描述了一名70岁的女性，她在首次复发时患有伴t(8;21)的急性髓性白血病，接受了氟达拉滨和低剂量全身照射（2Gy）预处理的非清髓性移植。骨髓抑制非常轻微，患者出现了短暂的I级肾和肝毒性。在第120天实现了完全嵌合。骨髓中AML1/MTG8融合基因水平在第56天降至检测不到的水平，患者存活且完全缓解，随访至第450天。这种移植方案甚至可能被老年患者很好地耐受，并带来持久缓解。
