[Disorders of specific humoral immunological response in children with febrile seizures].

The aim of the study was to analyse a few recent aspects concerning the humoral immunological response deficiency in children with febrile seizures. 33 children were involved in the study: 16 with a single fit of febrile seizures and 17 with more than one fit. Children's average age was 37.6 months. The control group consisted of 14 healthy children chosen according to the age criterion. In the last three weeks there were no symptoms of infection. Blood for immunological tests was taken in the interictal period. In each case blood was taken for evaluation of B lymphocytes subpopulation (CD19/CD5, CD19/CD10, CD19/CD21), T lymphocytes (CD4/CD45RA, CD4/CD45RO) and the proliferative response to the action of PWM and PHA mitogens. The concentrations of released IgA, IgG, IgM and subgroups of IgG were also measured. In the children's group with single febrile seizures there were statistically higher levels of lymphocytes: CD19/CD5 and CD19/CD21, lower level of T lymphocytes: CD4/CD45RA and CD4/CD45RO, poorer lymphocyte response to the action of PWM and PHA mitogens. Moreover there were lower concentrations of the total IgG and IgG2 and IgG4 subgroups. In children who had only one fit of febrile seizures, abnormalities in the conducted tests were expressed much more than in the control group and the children's group with the multiple febrile seizures. The results suggest that there is a connection between the genetic factors and the dysfunction of immunological system and the course of febrile seizures.