Iihara Masatoshi, Obara Takao
Dept. of Endocrine Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjyuku-ku, Tokyo 162-8666, Japan.
Gan To Kagaku Ryoho. 2004 Mar;31(3):342-5.
Adrenocortical carcinomas frequently hypersecrete multiple adrenocortical steroids and their precursors. CT scan and MRI usually demonstrate necrotic lesions or areas of calcification in this uncommon tumor. Therapy in patients with adrenocortical carcinoma is less satisfactory. Surgical excision is the primary mode of therapy. Up to the present, mitotane (o, p'-DDD) treatment combined with chemotherapy has been the only palliative measure for patients with nonresectable or extensively recurrent tumors.
肾上腺皮质癌常常过度分泌多种肾上腺皮质类固醇及其前体。CT扫描和MRI通常显示出这种罕见肿瘤中的坏死性病变或钙化区域。肾上腺皮质癌患者的治疗效果不太理想。手术切除是主要的治疗方式。到目前为止，米托坦（邻、对二氯二苯二氯乙烷）治疗联合化疗一直是不可切除或广泛复发肿瘤患者的唯一姑息性措施。
