Harano Masahiko, Kano Masako, Hida Tsukasa, Fujisawa Yasuhito, Kano Motonori
Kano Hospital.
Gan To Kagaku Ryoho. 2004 Mar;31(3):377-80.
An examination of the change in plasma concentration of OH-flutamide in low-dose flutamide (250 mg/day) monotherapy for 5 prostate cancer patients was performed. We treated 5 patients diagnosed with prostate cancer between September and November 2002. The plasma concentrations of OH-flutamide, PSA and AST/ALT were measured before and after low-dose flutamide monotherapy was started. The plasma concentrations of OH-flutamide were stable in the third day after medication was started, and even when compared with the plasma concentrations of OH-flutamide 375 mg/day, there was no significant difference. Although at the observation period was short, PSA fell favorably in all patients. The AST/ALT were in the normal range in all patients. The low-does flutamide therapy has been one of medical treatments if its safety and effectiveness has been demonstrated.
对5例前列腺癌患者采用低剂量氟他胺（250毫克/天）单药治疗时，对其血浆中羟基氟他胺浓度的变化进行了检测。我们对2002年9月至11月期间诊断为前列腺癌的5例患者进行了治疗。在开始低剂量氟他胺单药治疗前后，测定了羟基氟他胺、前列腺特异性抗原（PSA）和天冬氨酸转氨酶/丙氨酸转氨酶（AST/ALT）的血浆浓度。开始用药后第三天，羟基氟他胺的血浆浓度稳定，即使与375毫克/天的羟基氟他胺血浆浓度相比，也无显著差异。虽然观察期较短，但所有患者的PSA均呈良好下降趋势。所有患者的AST/ALT均在正常范围内。如果低剂量氟他胺疗法的安全性和有效性得到证实，它将成为治疗方法之一。
