Southern E M
Department of Biochemistry, Oxford University, UK.
Curr Opin Genet Dev. 1992 Jun;2(3):412-6. doi: 10.1016/s0959-437x(05)80151-0.
Clones of cDNAs have several practical advantages as start points for making physical maps of genomes: they are mainly single copy; they expand the map because of the introns in the genomic version of the gene; and they are conserved between species. They also address biologically important regions of the genome. Sequence information helps to identify new gene functions.
