Tsukioka Toshihide, Tomita Sigeyuki, Watanabe Go, Takemura Hirohumi
Department of General and Cardiothoracic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
Artif Organs. 2004 Mar;28(3):303-9. doi: 10.1111/j.1525-1594.2004.47279.x.
We were led to the premise that with retrograde oxygenated blood perfusion, it would be possible to perform operations on the beating heart.
The experiment consisted of two stages: procedure 1 and 2. In procedure 1, six pigs were used. Retrograde perfusion flow was controlled to be in the range of 5.0-10.0 mL/kg/min and was gradually increased. In procedure 2, six pigs were used. Retrograde perfusion was continued for 120 min at the optimal flow rate obtained from procedure 1.
The optimal flow rate was 7.0 mL/kg/min in procedure 1. In procedure 2, retrograde perfusions for 120 min were performed with perfusion flows set at optimal flow rate.
The procedure used in this study made it possible to maintain empty beating heart with normal sinus rhythm for 120 min, and the results suggest the possibility of clinical application to open heart surgery.
我们基于这样一个前提，即通过逆行氧合血灌注，有可能在跳动的心脏上进行手术。
实验包括两个阶段：步骤1和步骤2。在步骤1中，使用了6头猪。逆行灌注流量控制在5.0 - 10.0 mL/kg/min范围内并逐渐增加。在步骤2中，使用了6头猪。以步骤1中获得的最佳流量持续逆行灌注120分钟。
步骤1中的最佳流量为7.0 mL/kg/min。在步骤2中，以最佳流量设置进行了120分钟的逆行灌注。
本研究中使用的方法使得维持正常窦性心律的空跳心脏120分钟成为可能，结果提示了在心脏直视手术中临床应用的可能性。
