White Stacy, Uphouse Lynda
Department of Biology, Texas Woman's University, Denton, TX 76204-5799, USA.
Horm Behav. 2004 Mar;45(3):201-8. doi: 10.1016/j.yhbeh.2003.10.001.
Ovariectomized rats were hormonally primed with various doses of estradiol benzoate (EB; 0.5-10 microg) in combination with various doses of progesterone (2.5-500 microg) to induce sexual receptivity. Females were then subjected to 5 min restraint and the effect on lordosis behavior was monitored for the next 30 min. Such mild stress has been previously shown to transiently reduce lordosis behavior of ovariectomized females hormonally primed only with 10 microg EB. In the current study, doses of progesterone of 25 microg or more in combination with 10 microg EB reduced the effects of restraint. Also priming doses of EB from 4.0 to 10 microg in combination with 250 microg progesterone prevented the lordosis-inhibiting effects of restraint. These findings reinforce prior observations of the dose-dependency of both estrogen and progesterone in the facilitation of lordosis behavior and introduce the female's lordosis response to mild restraint as a potentially useful index of the female's response to stress.
对去卵巢大鼠用不同剂量的苯甲酸雌二醇（EB；0.5 - 10微克）与不同剂量的孕酮（2.5 - 500微克）进行激素预处理以诱导性接受能力。然后对雌性大鼠进行5分钟的束缚，并在接下来的30分钟内监测对脊柱前凸行为的影响。先前已表明，这种轻度应激会短暂降低仅用10微克EB进行激素预处理的去卵巢雌性大鼠的脊柱前凸行为。在当前研究中，25微克或更高剂量的孕酮与10微克EB联合使用可减轻束缚的影响。同样，4.0至10微克的EB预处理剂量与250微克孕酮联合使用可防止束缚对脊柱前凸的抑制作用。这些发现强化了先前关于雌激素和孕酮在促进脊柱前凸行为方面的剂量依赖性的观察结果，并引入了雌性大鼠对轻度束缚的脊柱前凸反应作为雌性大鼠对应激反应的潜在有用指标。
