Prosser R A, Heller H C, Miller J D
Department of Biological Sciences, Stanford University, CA 94305.
Brain Res. 1992 Feb 28;573(2):336-40. doi: 10.1016/0006-8993(92)90784-7.
The mammalian circadian clock in the suprachiasmatic nuclei (SCN) can be phase-shifted in vitro by the serotonin agonist quipazine. Here we show that quipazine resets the SCN clock in the presence of tetrodotoxin or 10 mM Mg2+, treatments that block Na+ action potentials and Ca2+ channels, respectively. These results support the hypothesis that quipazine resets the clock by stimulating receptors located on clock elements rather than on cells afferent to the clock.
