Rajab Khalil E, Skerman Jonathan H
Department of Obstetrics and Gynecology, College of Medicine and Medical Sciences, Arabian Gulf University and Salmaniya Medical Complex, Bahrain.
Saudi Med J. 2004 Mar;25(3):265-76.
Recent advances in the pathophysiology, clinical investigations, and management of sickle hemoglobinopathies enables all physicians to better manage these disease states and their sequelae. Patients with sickle cell disease SCD are living longer and are thus more likely to contract unrelated diseases that require surgery and anesthesia. Patients with SCD continue to be a challenge to all branches of medicine particularly in obstetrics, surgery and anesthesia; however, the armamentarium of new knowledge and practice places a different perspective on the care of this old disease. In general, the literature to date suggests that neither prophylactic transfusion of pregnant sicklers nor the selection of an anesthetic in labor have a major impact on patient outcome; however, perioperative management can greatly affect the consequences. A thorough knowledge of the impact of the disease on clinical status can determine how, when, and why to manage parturients with SCD.
镰状血红蛋白病在病理生理学、临床研究及治疗方面的最新进展，使所有医生能够更好地管理这些疾病状态及其后遗症。镰状细胞病（SCD）患者的寿命延长，因此更有可能患上需要手术和麻醉的无关疾病。SCD患者仍然是医学各领域的挑战，尤其是在产科、外科和麻醉科；然而，新知识和实践方法为这种古老疾病的护理带来了不同的视角。总体而言，迄今为止的文献表明，对患有镰状细胞病的孕妇进行预防性输血以及分娩时麻醉剂的选择，对患者预后均无重大影响；然而，围手术期管理会极大地影响最终结果。深入了解该疾病对临床状况的影响，能够确定如何、何时以及为何对患有SCD的产妇进行管理。
