Wiesbeck Gerhard A, Weijers Heinz-Gerd, Wodarz Norbert, Keller Heike K, Michel Tanja M, Herrmann Martin J, Boening Jobst
Department of Substance Use Disorders, Psychiatric University Clinic, University of Basel, Switzerland.
World J Biol Psychiatry. 2004 Jan;5(1):45-8. doi: 10.1080/15622970410029907.
We tested the hypothesis of an association between the serotonin transporter (5-HTT) gene regulatory region polymorphism and the Temperament and Character Inventory (TCI) personality dimension of Harm Avoidance. For the study, 124 subjects seeking inpatient treatment for primary alcohol dependence were grouped by their 5-HTT genotype and assessed with the TCI. Genotypes differed statistically significantly in Harm Avoidance but not in any other personality trait. This gives support to the hypothesis that the TCI temperament Harm Avoidance is associated with serotonergic neurotransmission in primary alcohol dependence.
我们检验了血清素转运体（5-HTT）基因调控区域多态性与《气质与性格问卷》（TCI）中回避伤害这一人格维度之间存在关联的假设。在这项研究中，124名因原发性酒精依赖寻求住院治疗的受试者按其5-HTT基因型分组，并接受TCI评估。基因型在回避伤害方面存在显著统计学差异，但在其他任何人格特质方面均无差异。这支持了以下假设：在原发性酒精依赖中，TCI气质的回避伤害与血清素能神经传递有关。
