Kim Jeong-Hee, Kim Hang-Keun, Lee Sang-Wha, Son Young-Don, Kim Jong-Hoon
Biomedical Engineering Research Center, Gachon University, Incheon 21936, Republic of Korea.
Department of Biomedical Engineering, College of IT Convergence, Gachon University, Seongnam-si 13120, Republic of Korea.
Pharmaceuticals (Basel). 2023 May 18;16(5):759. doi: 10.3390/ph16050759.
To elucidate the potential roles of serotonergic activity in human character traits (i.e., self-directedness, cooperativeness, and self-transcendence), we investigated the relationship between these character traits and serotonin transporter (5-HTT) in healthy subjects. Twenty-four participants underwent High-Resolution Research Tomograph-positron emission tomography scans with [C]DASB. To quantify 5-HTT availability, binding potential (BP) of [C]DASB was obtained using the simplified reference tissue model. The Temperament and Character Inventory was used to assess subjects' levels of three character traits. There were no significant correlations between the three character traits. Self-directedness was significantly positively correlated with [C]DASB BP in the left hippocampus, left middle occipital gyrus, bilateral superior parietal gyrus, left inferior parietal gyrus, left middle temporal gyrus (MTG), and left inferior temporal gyrus (ITG). Cooperativeness was significantly negatively correlated with [C]DASB BP in the median raphe nucleus. Self-transcendence was significantly negatively correlated with [C]DASB BP in the right MTG and right ITG. Our results show significant correlations between the three character traits and 5-HTT availability in specific brain regions. In particular, self-directedness was significantly positively correlated with 5-HTT availability, suggesting that a goal-oriented, self-confident, and resourceful character may be related to higher serotonergic neurotransmission.
为了阐明血清素能活性在人类性格特质（即自我导向、合作性和自我超越）中的潜在作用，我们研究了健康受试者中这些性格特质与血清素转运体（5-HTT）之间的关系。24名参与者接受了使用[C]DASB的高分辨率研究断层扫描-正电子发射断层扫描。为了量化5-HTT的可用性，使用简化参考组织模型获得了[C]DASB的结合潜力（BP）。气质和性格量表用于评估受试者三种性格特质的水平。三种性格特质之间没有显著相关性。自我导向与左海马体、左枕中回、双侧顶上回、左下顶叶、左颞中回（MTG）和左下颞叶（ITG）中的[C]DASB BP显著正相关。合作性与中缝核中的[C]DASB BP显著负相关。自我超越与右MTG和右ITG中的[C]DASB BP显著负相关。我们的结果表明，三种性格特质与特定脑区的5-HTT可用性之间存在显著相关性。特别是，自我导向与5-HTT可用性显著正相关，这表明目标导向、自信和机智的性格可能与更高的血清素能神经传递有关。
