Bashford J D, Jarvis P D
School of Mathematics and Physics, University of Tasmania, P. O. Box 252-37, Hobart 7001, Tasmania, Australia.
Biopolymers. 2004 Apr 15;73(6):657-67. doi: 10.1002/bip.20022.
We propose a simple algebraic description of the two-body interactions of bases in RNA thermodynamics showing in detail qualitative equivalence with conventional nearest-neighbor models. The process of obtaining base content, polymer, and oligomer parameters is illustrated, and for duplexes containing Watson-Crick pairs, fits to oligonucleotide duplex heat-of-formation data are shown to be statistically equivalent to existing models.
我们提出了一种RNA热力学中碱基二体相互作用的简单代数描述，详细展示了其与传统最近邻模型在定性上的等效性。文中说明了获取碱基含量、聚合物和寡聚物参数的过程，对于含有沃森-克里克碱基对的双链体，与现有模型相比，对寡核苷酸双链体生成热数据的拟合在统计学上是等效的。
