Ourednik Vaclav, Ourednik Jitka
Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, 50011, USA.
J Neurosci Res. 2004 Apr 15;76(2):193-204. doi: 10.1002/jnr.20037.
Current restorative neurotransplantation research focuses mainly on the potential of the neural graft to replace damaged or missing cell populations and to deliver needed gene products in the form of transgenes. Because of this graft-oriented bias of the procedure, possible dormant regenerative capabilities within the host have been largely underestimated and dismissed as insignificant. This review discusses existing evidence that neural grafts can have stimulating effects on host-intrinsic plasticity that can help regeneration of the mammalian central nervous system. If confirmed, the synergistic interaction between graft and host might substantially enhance our therapeutic possibilities.
当前的修复性神经移植研究主要集中在神经移植物替代受损或缺失细胞群以及以转基因形式递送所需基因产物的潜力上。由于该过程存在这种以移植物为导向的偏向，宿主内可能存在的潜在再生能力在很大程度上被低估并被认为无关紧要而被忽视。本文综述讨论了现有证据，即神经移植物可对宿主内在可塑性产生刺激作用，这有助于哺乳动物中枢神经系统的再生。如果得到证实，移植物与宿主之间的协同相互作用可能会大大增强我们的治疗可能性。
