Klijanienko Jerzy, Caillaud Jean-Michel, Lagacé Réal
Department of Tumor Biology, Institut Curie, Paris, France.
Diagn Cytopathol. 2004 Apr;30(4):261-5. doi: 10.1002/dc.20024.
Dermatofibrosarcoma protuberans (DFSP) is a nodular cutaneous mesenchymal tumor of intermediate malignancy. Studies on fine-needle aspiration of DFSP are extremely rare; to our knowledge, only 33 cases have been reported. We have reviewed 14 examples of DFSP in 13 patients. Ten primary tumors were aspirated before surgical biopsy and four recurrent lesions (all from superficial lesions) were also investigated by fine-needle aspiration. All smears were surprisingly homogeneous and composed of isolated spindle cells in all cases (one unsatisfactory smear is excluded). Tissue fragments with a stroriform pattern were seen in 11 cases, fibrillary stromal fragments in 10 cases, naked nuclei in 8 cases, slight to moderate cytonuclear atypia in 5 cases. Mitotic figures, myxoid background, mast cells, and dispersed adipocytes were rare. Giant cells, necrosis, or marked cytonuclear atypia were not seen. DFSP shares morphological characteristics of some low-grade spindle-cell neoplasms. It should be differentiated from other benign low- and intermediate-grade spindle neoplasm such as low-grade fibrosarcoma, fibromyxosarcoma, low-grade malignant peripheral nerve sheath tumor, benign peripheral nerve sheath tumor, nodular fasciitis, and fibrous histiocytoma.
隆突性皮肤纤维肉瘤（DFSP）是一种中度恶性的结节性皮肤间叶肿瘤。关于DFSP细针穿刺的研究极为罕见；据我们所知，仅报道了33例。我们回顾了13例患者的14例DFSP病例。10例原发性肿瘤在手术活检前进行了细针穿刺，4例复发病变（均来自浅表病变）也通过细针穿刺进行了研究。所有涂片均出奇地均匀，所有病例均由孤立的梭形细胞组成（排除1例不满意涂片）。11例可见束状模式的组织碎片，10例可见纤维性间质碎片，8例可见裸核，5例可见轻度至中度细胞核异型性。有丝分裂象、黏液样背景、肥大细胞和散在的脂肪细胞罕见。未见巨细胞、坏死或明显的细胞核异型性。DFSP具有一些低级别梭形细胞肿瘤的形态学特征。它应与其他良性低级别和中级别的梭形肿瘤相鉴别，如低级别纤维肉瘤、纤维黏液肉瘤、低级别恶性外周神经鞘瘤、良性外周神经鞘瘤、结节性筋膜炎和纤维组织细胞瘤。
